Organic Pollutants and Telomere Length: A New Facet of Carcinogenesis
نویسندگان
چکیده
Article history: Received 25 November 2015 Accepted 25 November 2015 Available online 26 November 2015 resulting in an increased likelihood of cells accumulating mutations necessary for neoplastic transformation (Noy, 2009). Little research has been done to link these two subjects in humans, but two studies have identified associations between PCBs and LTL (Mitro et al., 2015; Shin et al., 2010). In this issue of EBiomedicine, Scinicariello and Buser expand these results and identify associations
منابع مشابه
Low-dose persistent organic pollutants increased telomere length in peripheral leukocytes of healthy Koreans.
Although shortened telomeres have been found in many cancers, elongated telomere length has been observed as an early response after low-dose treatment with various chemical carcinogens in vitro and animal experiments, suggesting low-dose exposure to carcinogenic chemicals may function as a tumour promoter at the very early stage of carcinogenesis in humans. This cross-sectional study was perfo...
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BACKGROUND Exposure to persistent organic pollutants (POPs) such as dioxins, furans, and polychlorinated biphenyls (PCBs) may influence leukocyte telomere length (LTL), a biomarker associated with chronic disease. In vitro research suggests dioxins may bind to the aryl hydrocarbon receptor (AhR) and induce telomerase activity, which elongates LTL. However, few epidemiologic studies have investi...
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As the population ages, the occurrence of chronic pathologies becomes more common. Leukocyte telomere shortening associates to ageing and age-related diseases. Recent studies suggest that environmental chemicals can affect telomere length. Persistent organic pollutants (POPs) are most relevant, since they are ingested with foods, and accumulate in the body for a long time. This longitudinal stu...
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Background: Exercise and consumption of green tea affect the aging process. However, the effect of exercise training combined with green tea extract on leukocyte telomere length, quality of life (QoL) and body composition in aging has so far been unclear and inconsistent. Objective: The aim of the present study was to determine the effectiveness of aerobic training intervention and green tea e...
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